lipodystrophy susceptibility to partial acquired lipodystrophy 2021-10-28T07:52:14Z partial progressive lipodystrophy Medgen:C3887501 zmp lipodystrophy, cephalothoracic type Barraquer-Simons syndrome APLD, susceptibility to OMIM:608709 APLD Acquired partial lipodystrophy is characterized clinically by the gradual onset of bilaterally symmetrical loss of subcutaneous fat from the face, neck, upper extremities, thorax, and abdomen, in the 'cephalocaudal' sequence, sparing the lower extremities (summary by Misra et al., 2004). The disorder is not inherited in a classic mendelian pattern; it rather represents a phenotype with a complex etiology. Affected individuals may have genetic susceptibility factors that require the additional presence of environmental factors or acquired disorders to be expressed (summary by Hegele et al., 2006). Most cases are sporadic, family history is negative, and females are more often affected than males (ratio, 4:1).