spastic paraplegia 84, autosomal recessive 2022-01-31T14:30:59Z Zoe May Pendlington OMIM:619621 Autosomal recessive spastic paraplegia-84 (SPG84) is characterized by onset of slowly progressive walking difficulties due to lower limb weakness, stiffness, and spasticity in the first 2 decades of life. Additional features may include nystagmus, urinary urgency, joint contractures, and possible learning disabilities. Genetic neurodegenerative disease