pseudo-bulk aggregation of single-cell expression data pseudo-bulk aggregation of single-cell ATAC-seq data 2023-06-30T08:56:09Z A processed matrix generation method that involves combining (binary or quantitative) single-cell ATAC seq data from multiple cells within the same biological sample and/or cell types, depending on the intended downstream values. Ideally, aggregation is done within predefined regions of the genome e.g., using called peaks or tiles across the genome. The aggregated profiles can then be used in the same manner as bulk ATAC-seq or DNase-seq data. pseudo-bulk ATAC-seq An example of an applied case of pseduo-bulk scATAC-seq data to facilitate comparisons between traditional DNase/ATAC data and single-cell studies: https://pubmed.ncbi.nlm.nih.gov/29539636. pseduo-bulk scATAC-seq data