hereditary amyloidosis hereditary ATTR amyloidosis A rare genetic systemic disease characterized by adult onset, progressive sensorimotor and autonomic neuropathy and infiltrative cardiomyopathy. Neurological involvement usually starts with sensory loss in the extremities and progresses with motor neuropathy. Cardiomyopathy presents with rhythm abnormalities and heart failure. The disease also frequently manifests with a range of additional clinical signs and symptoms due to associated ocular, renal, central nervous system and gastrointestinal involvement. familial TTR-related amyloidosis hereditary ATTR amyloidosis UMLS:CN227096 familial transthyretin-related amyloidosis Term added in response to Mondo restructuring. To be considered for replacement or obsoletion in EFO also. Orphanet:271861