intestinal disorder familial infantile gigantism hereditary infantile gigantism infantile gigantism due to pituitary hyperplasia A rare, genetic pituitary disease characterized by infantile-onset, rapid and excessive acceleration of linear growth and body size due to mixed growth hormone (GH)- and prolactin-secreting adenomas and/or pituitary hyperplasia. Patients present with gigantism and may have associated acromegalic features (e.g. coarse facial features, frontal bossing, prognathism, increased interdental space) as well as marked enlargement of hands and feet, soft tissue swelling, increased appetite and acanthosis nigricans. Orphanet:300373 X-LAG (X-linked acrogigantism) hereditary pituitary hyperplasia UMLS:CN203384 Term added in response to Mondo restructuring. To be considered for replacement or obsoletion in EFO also.