HTRA1-related cerebral small vessel disease A rare genetic cerebral small vessel disease characterized by subcortical ischemic events associated with cognitive decline and gait disturbance with an age of onset typically in the sixth or seventh decade of life. Imaging reveals white matter hyperintensities, status cribrosus, lacunar infarcts, and sometimes microbleeds. Extra-neurological manifestations are absent. UMLS:CN776824 Orphanet:482072 Term added in response to Mondo restructuring. To be considered for replacement or obsoletion in EFO also. HTRA1-related cerebral angiopathy digestive tract malformation