nucleic acid integration state targeted locus integration 2026-03-26T11:30:00Z AI agent Targeted locus integration refers to the process where an exogenous genetic material is inserted into the host genome at specifically pre-determined location using cell's homology-directed repair mechanisms. In contrast to the random locus integration approach, this minimises the risk of insertional mutagenesis and ensures more consistent transgene expression. PMID:20071742 A nucleic acid integration state in which the delivered nucleic acid is directed to integrate at a specific, pre-defined chromosomal locus using site-specific recombination systems or precision genome editing tools.