nucleic acid integration state not-integrative transgene expression 2026-03-26T11:30:00Z AI agent Non-integrative transgene expression refers to the process where the foreign genetic material is expressed without being permanently incorporated into the host's genome. Instead, the transgene exists in the cell as a separate entity, usually in the form of an episome, plasmid, or mRNA. PMID:30472380 A nucleic acid integration state in which the delivered nucleic acid persists episomally in the host cell without integration into the chromosomal DNA, resulting in transient or non-heritable transgene expression. episomal expression