obsolete_Rienhoff syndrome true http://purl.obolibrary.org/obo/MONDO_0014262 3.88.0 Replaced by Mondo term MONDO_0014262, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0014262 Loeys-Dietz syndrome-5 OMIM:615582 LDS5 Loeys-Dietz syndrome-5 (LDS5), also known as Rienhoff (pronounced REENhoff) syndrome, is characterized by syndromic presentation of aortic aneurysms involving the thoracic and/or abdominal aorta, with risk of dissection and rupture. Other systemic features include cleft palate, bifid uvula, mitral valve disease, skeletal overgrowth, cervical spine instability, and clubfoot deformity; however, not all clinical features occur in all patients. In contrast to other forms of LDS, no striking aortic or arterial tortuosity is present in these patients, and there is no strong evidence for early aortic dissection. Loeys-Dietz syndrome 5