obsolete_Digestive System Adenoma true Replaced by Mondo term MONDO_0006180, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0006180 3.88.0 DOID:4147 http://purl.obolibrary.org/obo/MONDO_0006180 NCIT:C36207 gastrointestinal adenoma A sporadic or less frequently familial neoplasm, arising from the glandular epithelium of the stomach, small intestine, biliary tract, colon, and rectum. It is a polypoid or flat circumscribed lesion. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. The frequency of malignant transformation depends on the size of the lesion and the degree of dysplasia. Larger adenomas with severe dysplastic changes (sometimes called carcinoma in situ) carry a higher risk of progressing to invasive adenocarcinoma. Gastrointestinal adenomas may present as solitary or multifocal lesions. Familial adenomas tend to be multifocal and carry a higher risk of malignant transformation. GI adenoma digestive system adenoma UMLS:C0948101 digestive tract adenoma EFO:1000217