obsolete_Vulvar Squamous Cell Carcinoma true EFO:1000624 epidermoid cell carcinoma of the vulva vulva epidermoid cell carcinoma Orphanet:494448 3.88.0 vulvar epidermoid carcinoma epidermoid cell carcinoma of vulva mammalian vulva squamous cell carcinoma SCTID:254895003 squamous cell carcinoma of the vulva vulvar epidermoid cell carcinoma vulva squamous cell carcinoma UMLS:C0280856 squamous cell carcinoma of vulva vulvar squamous cell carcinoma NCIT:C4052 epidermoid carcinoma of vulva An invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003) DOID:2101 http://purl.obolibrary.org/obo/MONDO_0024609 vulva epidermoid carcinoma Replaced by Mondo term MONDO_0024609, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0024609 epidermoid carcinoma of the vulva vulvar squamous cell cancer