hereditary disease apparent mineralocorticoid excess syndrome MESH:D043204 DOID:4367 A hereditary disease characterized by childhood onset HYPERTENSION, hypokalemic alkalosis, and low RENIN and ALDOSTERONE secretion. It results from a defect in the activity of the 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 enzyme which results in inadequate conversion of CORTISOL to CORTISONE. The build up of unprocessed cortisol to levels that stimulate MINERALOCORTICOID RECEPTORS creates the appearance of having excessive MINERALOCORTICOIDS. syndrome of apparent mineralocorticoid excess (disorder) SNOMEDCT:237770005 Mineralocorticoid Excess Syndrome, Apparent Sirarat Sarntivijai