obsolete_central pontine myelinolysis true Sirarat Sarntivijai http://purl.obolibrary.org/obo/MONDO_0006692 MESH:D017590 NCIt:C84623 DOID:636 Replaced by Mondo term MONDO_0006692, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0006692 central pontine myelinolysis (disorder) ICD10:G37.2 Myelinolysis, Central Pontine MedDRA:10007968 central pontine myelinosis A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6) 3.88.0 SNOMEDCT:6807001