brain disorder perinatal disease kernicterus ICD10:P57 Kernicterus of newborn NOS (disorder) DOID:2382 MedDRA:10023376 MESH:D007647 SNOMEDCT:74925009 A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613) Kernicterus bilirubin encephalopathy NCIt:C84799 Kernicterus of newborn (disorder) Sirarat Sarntivijai