obsolete_SAPHO syndrome true true Acquired Hyperostosis Syndrome Dani Welter Replaced by Mondo term MONDO_0019266, with which this term was previously merged. Use: http://purl.obolibrary.org/obo/MONDO_0019266 NCIt:C119049 MedDRA:10051316 SNOMEDCT:60684003 3.88.0 Synovitis, acne, pustulosis palmaris, hyperostosis, osteomyelitis syndrome http://purl.obolibrary.org/obo/MONDO_0019266 MESH:D020083 DOID:13677 Syndrome consisting of SYNOVITIS; ACNE CONGLOBATA; PALMOPLANTAR PUSTULOSIS; HYPEROSTOSIS; and OSTEITIS. The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome.