part_of part of part of has_disease_location endothelial cell vascular disorder endothelium endothelial dysfunction Wikipedia:Endothelial_dysfunction Gautier Koscielny MedDRA:10048554 In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium (the inner lining of blood vessels) and can be broadly defined as an imbalance between vasodilating and vasoconstricting substances produced by (or acting on) the endothelium. Normal functions of endothelial cells include mediation of coagulation, platelet adhesion, immune function and control of volume and electrolyte content of the intravascular and extravascular spaces.