Neurogenic arthrogryposis multiplex congenita Neurogenic arthrogryposis multiplex congenital is a form of arthrogryposis multiplex congenital (AMC; see this term), characterized by congenital immobility of the limbs with fixation of multiple joints and muscle wasting. This condition is caused by neurogenic muscular atrophy. MESH:C536614 ICD10:Q74.3 orphanet UMLS:C1859721 OMIM:617468 OMIM:208100 Genetic syndrome with limb malformations as a major feature