Cerebellar ataxia - hypogonadism Cerebellar ataxia - hypogonadism, also known as Gordon-Holmes syndrome, is a very rare autosomal recessive neurodegenerative disorder characterized by the combination of progressive cerebellar ataxia with onset from early childhood to the fourth decade, and hypogonadotropic hypogonadism (delayed puberty and lack of secondary sex characteristics). Cerebellar ataxia - hypogonadism belongs to a clinical continuum of neurodegenerative disorders along with clinically overlapping disorders such as Ataxia - hypogonadism - choroidal dystrophy (see this term). Gordon-Holmes syndrome orphanet ICD10:G11.8 Luteinizing hormone-releasing hormone deficiency with ataxia OMIM:212840 OMIM:605672 Rare disorder with hypogonadotropic hypogonadism Rare hereditary ataxia