mental disorder CADASIL true MedDRA:10065551 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy Hereditary multi-infarct dementia MESH:D046589 ICD10:F01.1 UMLS:C0751587 CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary cerebrovascular disorder characterized by mid-adult onset of recurrent subcortical ischemic stroke and cognitive impairment progressing to dementia in addition to migraines with aura and mood disturbances seen in about a third of patients. OMIM:125310 orphanet MedDRA:10065555 Genetic cerebrovascular dementia