obsolete_Lynch syndrome true familial non-polyposis colon cancer (hMSH2, hMLH1, hPMS1, hPMS2) Hereditary non-polyposis colon cancer (hMSH2, hMLH1, hPMS1, hPMS2) Sometimes Lynch syndrome is also referred to as hereditary non-polyposis colorectal cancer (HNPCC), but the two conditions are subtly different. Lynch syndrome is classified by a mutation in mismatch repair genes. It is diagnosed by specific criteria known as the Amsterdam criteria. hereditary nonpolyposis colorectal cancer EFO:0007354 Hereditary nonpolyposis colon cancer (hMSH2, hMLH1, hPMS1, hPMS2) An autosomal dominant hereditary neoplastic syndrome characterized by the development of colorectal carcinoma and a high risk of developing endometrial carcinoma, gastric carcinoma, ovarian carcinoma, renal pelvis carcinoma, and small intestinal carcinoma. Patients often develop colorectal carcinomas at an early age (mean, 45 years). In the majority of the cases the lesions arise from the proximal colon. At the molecular level, high-frequency microsatellite instability is present. DOID:3883 https://my.clevelandclinic.org/health/diseases/17195-lynch-syndrome--hnpcc Lynch syndrome Replaced with Mondo term. https://github.com/monarch-initiative/mondo/issues/1673 Hereditary colorectal endometrial cancer syndrome MedDRA:10051981 Orphanet:144 HNPCC - hereditary nonpolyposis colon cancer hereditary non-polyposis colon cancer type 1 NCIT:C8494 SCTID:716318002 ICD10:D48.9 hereditary nonpolyposis colorectal neoplasm 3.41.0 hereditary defective mismatch repair syndrome http://purl.obolibrary.org/obo/MONDO_0005835 https://www.sciencedirect.com/topics/medicine-and-dentistry/amsterdam-criteria