has_disease_location ovarian epithelial tumor ovarian cancer breast ovary Hereditary breast and ovarian cancer syndrome BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) hereditary breast and ovarian cancer NCIT:C8493 GARD:0012352 GARD:0012351 hereditary breast ovarian cancer Editor note: https://github.com/monarch-initiative/mondo/issues/84 DOID:5683 SCTID:718220008 OMIMPS:604370 UMLS:C0677776 syndromes, HBOC HBOC syndromes ICD10:C56 MESH:D061325 hereditary breast ovarian cancer syndrome familial breast and ovarian cancer syndrome hereditary breast and ovarian cancer syndrome familial breast/ovarian cancer (BRCA1, BRCA2) An autosomal dominant inherited syndrome caused by mutations in the BRCA1 or BRCA2 genes. Patients are at high risk of developing breast cancer, particularly before the age of fifty, high risk of developing a second primary breast cancer, and high risk of developing both breast and ovarian cancer. ICD10:C50 BRCA1- and BRCA2-associated hereditary breast and ovarian cancer breast-ovarian cancer, familial, susceptibility to syndrome, HBOC Orphanet:145 DC:0000638 HBOC syndrome hereditary breast/ovarian cancer (BRCA1, BRCA2) Hereditary breast cancer