obsolete_MASA syndrome true UMLS:C0795953 ICD10:G11.4 OMIM:303350 MASA syndrome (Mental retardation, Aphasia, Spastic paraplegia, Adducted thumbs) is a historical term used to describe a phenotype now considered to be part of the X-linked L1 clinical spectrum (L1 syndrome, see this term). MASA is characterized by adducted thumbs, hypotonia progressing to spasticity or spastic paraplegia, delayed development of speech, mild to moderate intellectual deficit, and mild to moderate distension of the cerebral ventricles. Replaced with Mondo term. MESH:C536029 http://purl.obolibrary.org/obo/MONDO_0010559 3.41.0 Intellectual disability-aphasia-shuffling gait-adducted thumbs syndrome orphanet