Retinal vasculopathy and cerebral leukodystrophy Retinal vasculopathy and cerebral leukodystrophy (RVCL) is an inherited group of small vessel diseases comprised of cerebroretinal vasculopathy (CRV), hereditary vascular retinopathy (HRV) and hereditary endotheliopathy with retinopathy, nephropathy and stroke (HERNS; see these terms); all exhibiting progressive visual impairment as well as variable cerebral dysfunction. orphanet OMIM:192315 RVCL Rare genetic neurological disorder Genetic vitreous-retinal disease