otopalatodigital syndrome X-linked syndromic intellectual disability Syndromic developmental defect of the eye Osteodysplasty, Melnick-Needles type MedDRA:10060908 UMLS:C0025237 ICD10:Q77.8 Osteodysplasty, Melnick-Needles type (MNS) is a severe form of frontootopalatodigital syndrome (see this term) and is associated with a short stature, facial dysmorphism, osseous abnormalities involving the majority of the axial and appendicular skeleton resulting in significant effects on the craniofacial skeleton including impaired speech and masticatory problems. Melnick-Needles syndrome orphanet OMIM:309350 Rare disease with glaucoma as a major feature