Genetic renal or urinary tract malformation Arthrogryposis - renal dysfunction - cholestasis ARC syndrome ICD10:Q89.7 UMLS:C1859722 MESH:C535382 OMIM:208085 orphanet Arthrogryposis-Renal dysfunction-Cholestasis (ARC) syndrome is a multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with low serum gamma-glutamyl transferase activity. OMIM:613404 Autosomal ichthyosis syndrome with fatal disease course Disorder of bilirubin metabolism and excretion Genetic syndrome with limb malformations as a major feature