obsolete_Costello syndrome true Intellectual disability - nasal papillomata MedDRA:10067380 Replaced with Mondo term. 3.41.0 FCS syndrome http://purl.obolibrary.org/obo/MONDO_0009026 orphanet UMLS:C0587248 Faciocutaneoskeletal syndrome OMIM:218040 Costello syndrome (CS) is a rare multisystemic disorder characterized by failure to thrive, short stature, developmental delay or intellectual disability, joint laxity, soft skin, and distinctive facial features. Cardiac and neurological involvement is common and there is an increased lifetime risk of certain tumors. MESH:D056685 ICD10:Q87.8