Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia ALSP OMIM:221820 Familial progressive subcortical gliosis Familial dementia, Neumann type Autosomal dominant leukoencephalopathy with neuroaxonal spheroids POLD FPSG GPSC ICD10:E75.2 Hereditary diffuse leukoencephalopathy with spheroids orphanet Pigmentary orthochromatic leukodystrophy Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia is a rare autosomal dominant disease characterized by a complex phenotype including progressive dementia, apraxia, apathy, impaired balance, parkinsonism, spasticity and epilepsy. Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Subcortical gliosis of Neumann HDLS Rare genetic neurological disorder