obsolete_Coats plus syndrome true orphanet Coats plus syndrome is a pleiotropic multisystem disorder characterized by retinal telangiectasia and exudates, intracranial calcification with leukoencephalopathy and brain cysts, osteopenia with predisposition to fractures, bone marrow suppression, gastrointestinal bleeding and portal hypertension. It is transmitted as an autosomal recessive disease. CRMCC ICD10:H35.0 3.41.0 OMIM:617341 Replaced with Mondo term. Cerebroretinal microangiopathy with calcifications and cysts OMIM:612199 http://purl.obolibrary.org/obo/MONDO_0012815