Tetraamelia - multiple malformations ICD10:Q87.8 MESH:C536500 Tetraamelia - multiple malformations is an extremely rare mostly lethal congenital disorder characterized by absence of all four limbs and frequent associated major malformations involving the head, face, eyes, skeleton, heart, lungs, anus, urogenital, and central nervous systems. The syndrome has been described in fewer than 20 patients mainly of middle Eastern descent. orphanet UMLS:C2931218 OMIM:618021 OMIM:273395 Zimmer phocomelia Genetic syndrome with limb reduction defects