obsolete_Frontootopalatodigital syndrome true 3.41.0 Replaced with Mondo term. Frontootopalatodigital syndrome is a group of congenital anomalies that span a broad range of clinical severity. This group include different conditions ranging from otopalatodigital syndrome type 1 (OPD1) which is characterized in affected males by cleft palate, conductive hearing loss, craniofacial abnormalities and a skeletal dysplasia, to osteodysplasty, Melnick-Needles type (MNS) which displays skeletal deformities in females and embryonic or perinatal lethality in males. Within this spectrum includes otopalatodigital syndrome type 2 (OPD2), frontometaphyseal dysplasia (FMD) and Frank-ter Haar syndrome (formerly considered as an autosomal recessive form of MNS) (see these terms). Frontootopalatodigital osteodysplasia orphanet http://purl.obolibrary.org/obo/MONDO_0018233