Genetic skeletal muscle disease Glycogen storage disease with hypertrophic cardiomyopathy Lysosomal disease with hypertrophic cardiomyopathy Lysosomal disease with restrictive cardiomyopathy Glycogen storage disease due to acid maltase deficiency UMLS:C0017921 Glycogenosis type 2 GSD type 2 MedDRA:10053185 Glycogen storage disease type 2 Glycogen storage disease due to acid maltase deficiency (AMD) is an autosomal recessive trait leading to metabolic myopathy that affects cardiac and respiratory muscles in addition to skeletal muscle and other tissues. AMD represents a wide spectrum of clinical presentations caused by an accumulation of glycogen in lysosomes: Glycogen storage disease due to acid maltase deficiency, infantile onset, non-classic infantile onset and adult onset (see these terms). Early onset forms are more severe and often fatal. GSD due to acid maltase deficiency Pompe disease MESH:D006009 Alpha-1,4-glucosidase acid deficiency orphanet ICD10:E74.0 Glycogenosis due to acid maltase deficiency OMIM:232300 Lysosomal disease Disorder of carbohydrate metabolism