Genetic skeletal muscle disease Genetic periodic paralysis DOID:1029 familial periodic paralysis ICD10:G72.3 paralyses, familial periodic familial periodic paralyses A heterogenous group of inherited disorders characterized by recurring attacks of rapidly progressive flaccid paralysis or myotonia. These conditions have in common a mutation of the gene encoding the alpha subunit of the sodium channel in skeletal muscle. They are frequently associated with fluctuations in serum potassium levels. Periodic paralysis may also occur as a non-familial process secondary to THYROTOXICOSIS and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1481) Paralyses, Familial Periodic MESH:D010245