part_of part of part of has_disease_location cold urticaria zone of skin Rare genetic systemic or rheumatologic disease Autoinflammatory syndrome with immune deficiency Familial cold urticaria Gautier Koscielny FCAS1 OMIM:616115 MedDRA:10064570 orphanet Familial cold autoinflammatory syndrome ICD10:L50.2 OMIM:120100 FCAS MedDRA:10071094 Familial cold urticaria (FCAS) is the mildest form of cryopyrin-associated periodic syndrome (CAPS; see this term) and is characterized by recurrent episodes of urticaria-like skin rash triggered by exposure to cold associated with low-grade fever, general malaise, eye redness and arthralgia/myalgia. UMLS:C0343068 FCU