obsolete_alkaline ceramidase 3 deficiency true OMIM:617762 http://purl.obolibrary.org/obo/MONDO_0044718 ACER3-related early childhood-onset progressive leukodystrophy leukodystrophy due to alkaline ceramidase 3 deficiency A form of leukodystrophy, a disorder of myelin production or maintenance affecting the central nervous system. PELCO features include neurological regression between 6 and 13 months of age, truncal hypotonia, appendicular spasticity, dystonia, optic disk pallor, peripheral neuropathy and neurogenic bladder. Brain imaging shows progressive diffuse abnormal white matter signals, cerebral atrophy, and thin corpus callosum. Sural nerve biopsy shows decreased myelination. PLDECO inheritance is autosomal recessive. Replaced with Mondo term. 3.41.0