Malformation syndrome with connective tissue involvement Syndrome or malformation associated with head and neck malformations Primary bone dysplasia Rare bone disease related to a common gene or pathway defect Autosomal dominant Larsen syndrome ICD10:Q68.8 Larsen syndrome (LS) is a rare skeletal dysplasia characterized by congenital dislocation of large joints, foot deformities, cervical spine dysplasia, scoliosis, spatula-shaped distal phalanges and distinctive craniofacial abnormalities, including cleft palate. OMIM:150250 orphanet UMLS:C2931648