Rare genetic bone disease Genetic cranial malformation Rare genetic bone development disorder Craniosynostosis - intracranial calcifications orphanet Craniosynostosis - intracranial calcifications is a rare syndromic craniosynostosis with unknown etiology characterized by variable degrees of craniosynostosis and basal ganglia calcifications with the inconsistent association of mild dysmorphic facies with prominent eyes and nasal bridge. Intelligence is not affected. Craniosynostosis - intracranial calcifications appears to be transmitted in an autosomal recessive manner. OMIM:608432 Longman-Tolmie syndrome ICD10:Q87.0