Genetic bone tumor Diaphyseal medullary stenosis - bone malignancy GARD:0010072 diaphyseal medullary stenosis-bone malignancy syndrome myopathy, limb-girdle, with bone fragility DMS-MFH BDMF diaphyseal medullary stenosis with malignant fibrous histiocytoma bone dysplasia-medullary fibrosarcoma syndrome Hardcastle's syndrome Diaphyseal medullary stenosis with malignant fibrous histiocytoma is a very rare autosomal dominant bone dysplasia/cancer syndrome characterized clinically by bone infarctions, cortical growth abnormalities, pathological fractures, and development of bone sarcoma (malignant fibrous histiocytoma). OMIM:112250 diaphyseal medullary stenosis-malignant fibrous histiocytoma syndrome DMSMFH UMLS:C1862177 ICD10:M89.8 Hardcastle syndrome bone dysplasia with medullary fibrosarcoma Orphanet:85182 NCIT:C122660 bone dysplasia with malignant fibrous histiocytoma