obsolete_AL amyloidosis true UMLS:C0268381 orphanet OMIM:254500 MedDRA:10036673 Immunoglobulinic amyloidosis Replaced with Mondo term. http://purl.obolibrary.org/obo/MONDO_0019438 AL Amyloidosis is a plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor (see this term). It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA; see these terms) restricted to a single organ. Light-chain amyloidosis 3.41.0 ICD10:E85.8 Primary amyloidosis Gautier Koscielny Systemic monoclonal immunoglobulin light chain amyloidosis systemic AL amyloidosis MESH:C531616