Rare genetic neurological disorder Disorder of carbohydrate metabolism Triose phosphate-isomerase deficiency OMIM:615512 ICD10:D55.2 orphanet UMLS:C0398562 Triosephosphate isomerase (TPI) deficiency is a severe autosomal recessive inherited multisystem disorder of glycolytic metabolism characterized by hemolytic anemia and neurodegeneration. Hemolytic anemia due to a disorder of glycolytic enzymes