obsolete_8p inverted duplication/deletion syndrome true Inverted 8p duplication/deletion syndrome 8p inverted duplication/deletion [invdupdel(8p)] syndrome is a rare chromosomal anomaly characterized clinically by mild to severe intellectual deficit, severe developmental delay (psychomotor and speech development), hypotonia with tendency to develop progressive hypertonia and severe orthopedic problems over time, minor facial anomalies and agenesis of the corpus callosum. ICD10:Q99.8 http://purl.obolibrary.org/obo/MONDO_0019876 Invdupdel(8p) orphanet Replaced with Mondo term. 3.41.0