intermediate cell of urothelium of primitive bladder true anatomical_structure EMAPA:36086 intermediate cell of urothelium of primitive bladder (ICs) (TS:21-TS:21): are defined by their expression pattern and location in the urothelium. They are present from TS:21, in the primitive bladder they are located below the luminal cells and they express Uroplakins, Trp63 and Shh (and do not express Foxa2, Isl1 or Krt5). Intermediate cells are present in the bladder (after TS:21).