part_of starts_at ends_at male accessory gland prostate bud The prostate bud (syn: prostatic bud, prostate gland bud) (TS:24-TS:27). Androgens produced by the male, leads to the formation of numerous prostate buds, which develop from the epithelium of the pelvic urethra in distinct locations. Anterior and dorsal prostatic buds are the first to emerge at E16.5 (TS:24) and later lateral and ventral buds at E17.5 (TS:25). Prostate buds emerge from the epithelium in the location of the mesenchymal pads. Comprised of epithelium of prostate bud (derived from the urogenital sinus epithelium) and peri-prostatic mesenchyme of prostate bud. Epithelial layer of prostate bud is selectively marked by Wnt10b (E17 to P0, in all prostate bud regions) and is also marked by Nkx3-1 at E16 to P0 (also expressed in urethral gland buds, E16 to P0). In the prostate gland, Bmp2 is selectively expressed by epithelium of ventral prostate bud at E17. Prostate bud formation is complete by E18.5 (TS:26) and elongation and differentiation continues after birth. The different prostate bud regions show differences in size, patterning and location. anatomical_structure prostatic bud prostate gland bud EMAPA:36141 lower urogenital tract of male TS24 TS27