alternating hemiplegia of childhood true DOID:0050635 OMIM:104290 OMIM:614820 GARD:11 MESH:C536589 disease_ontology Alternating hemiplegia of childhood is a rare disorder, with onset in the first year of life, characterised by recurrent attacks of hemiplegia affecting either side of the body. There may be bilateral weakness from the onset of episodes or during the attacks. Attacks may last minutes to more than half an hour. Other signs include nystagmus, pallor, crying, eye deviation, autonomic symptoms and dystonic and tonic elements during the episodes, with choreoathetosis between episodes. Events may be mistaken for focal seizures. Parkinsonian features may develop over time. Events may be triggered by stress, water, certain foods and exercise. Sleep allows the symptoms in an episode to resolve, however they may return 10-20 minutes after waking. Affected infants have learning disability and abnormal motor development. A significant proportion of individuals will also have focal seizures. The vast majority of individuals (about 80%), have mutations in the ATP1A3 gene. Xref MGI. OMIM mapping confirmed by DO. [SN]. ORDO:2131 ICD10CM:G98 AHC A hemiplegia characterized by recurrent episodes of temporary weakness or complete paralysis on one or both sides of the body. Alternating hemiplegia rare paroxysmal movement disorder