early infantile epileptic encephalopathy true true true A neonatal period electroclinical syndrome that is characterized by tonic spasms and partial seizures. GARD:9255 2012-05-10T10:02:58Z Ohtahara syndrome DOID:0050709 OMIM:PS308350 ORDO:1934 Early Infantile Epileptic Encephalopathy with Burst-Suppression disease_ontology DOID:2481 Ohtahara syndrome (also known as early infantile epileptic encephalopathy, EIEE) is a syndrome characterized by frequent intractable seizures and severe early encephalopathy resulting in limited development and reduced life expectancy. Tonic seizures predominate, myoclonic seizures are uncommon, distinguishing this syndrome from early myoclonic encephalopathy. Treatable metabolic etiologies (especially pyridoxine and pyridoxal-5-phosphate disorders) should be excluded early. lschriml neonatal/infantile epilepsy syndrome