autosomal dominant nocturnal frontal lobe epilepsy true ENFL A frontal lobe epilepsy that is characterized by autosomal dominant inheritance with childhood onset of clusters of brief nocturnal motor seizures with hyperkinetic or tonic manifestations. OMIM:PS600513 Autosomal dominant nocturnal frontal lobe epilepsy is a familial epilepsy with focal seizures beginning most commonly in childhood, although sporadic cases may occur. Brief nocturnal frontal lobe seizures with hyperkinetic, tonic or dystonic motor features are seen. Treatment with low dose carbamazepine is effective, however 30% of cases are resistant to treatment. Interictal EEG is often normal but may show anterior epileptiform abnormalities, typically in sleep. Mutations have been identified in genes coding for different subunits of the neuronal nicotinic acetylcholine receptors in 15% of familial cases, and in some sporadic cases. DOID:0060681 http://www.case.edu/EpSO.owl#AutosomalDominantNocturnalFrontalLobeEpilepsy ADNFLE disease_ontology https://www.ncbi.nlm.nih.gov/books/NBK83677/ GARD:11918 ORDO:98784 childhood-onset epilepsy syndrome