Alzheimer's disease true true Alzheimer disease Xref MGI. OMIM mapping confirmed by DO. [SN]. GARD:10254 MESH:D000544 ICD9CM:331.0 EFO:0000249 UMLS_CUI:C0002395 A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. NCI:C2866 ICD10CM:G30 SNOMEDCT_US_2018_03_01:73768007 CSP2005:0485-6737 https://www.ncbi.nlm.nih.gov/pubmed/29213881 SNOMEDCT_US_2018_03_01:26929004 ICD10CM:G30.9 DOID:10652 Alzheimers dementia disease_ontology KEGG:05010 tauopathy