progressive myoclonus epilepsy true true A variable age at onset electroclinical syndrome characterised by a relentlessly progressive disease course until death. OMIM:310370 SNOMEDCT_US_2018_03_01:89480000 progressive Myoclonus epilepsy OMIM:PS254800 progressive myoclonic epilepsy Progressive myoclonus epilepsy should considered in a patient with myoclonic seizures, with or without generalized tonic-clonic seizures in the following settings: Progressive cognitive decline , Myoclonus resulting in progressive motor impairment, Cerebellar signs , Background slowing on EEG (particularly if increasing over time), Myoclonus that is refractory to trials of appropriate anti-seizure medication MESH:D020191 PME GARD:7140 NCI2004_11_17:C7636 OMIM mapping confirmed by DO. [SN]. OMIM mapping submitted by NeuroDevNet. [LS]. DOID:891 NCI:C7636 UMLS_CUI:C0751778 disease_ontology variable age onset epilepsy