peroxisomal disease true ICD9CM:277.86 An inherited metabolic disorder that involves peroxisome malfunction. DOID:906 disease_ontology peroxisomal disorder NCI:C85005 ICD10CM:E71.5 Peroxisomal disorder UMLS_CUI:C0282528 ICD10CM:E71.50 MESH:D018901 ICD9CM_2006:277.86 Peroxisomal disorders are an uncommon cause of epilepsy, usually presenting with seizures in early life, in a neonate or infant with severe neurological impairment. Malformations of cortical development may co-occur in specific peroxisomal disorders, including Zellweger syndrome and neonatal adrenoleucodystrophy. Focal seizures, generalized seizures and epileptic spasms may occur. Diagnosis is through identification of abnormal levels of very long chain fatty acids. metabolic etiology