signal transduction intrinsic apoptotic signaling pathway true The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595. https://www.ncbi.nlm.nih.gov/pubmed/17371290 biological_process 2011-11-23T09:40:50Z GO:0097193 GO:0008629 induction of apoptosis by intracellular signals paola A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). mitochondrial-mediated apoptotic pathway intrinsic apoptotic pathway intrinsic apoptotic signalling pathway intrinsic apoptosis