brain disease nodular neuronal heterotopia true http://www.case.edu/EpSO.owl#NodularHeterotopias ICD10:Q04.8 Orphanet:2149 hereditary nodular heterotopia GARD:0002661 Nodular Heterotopias genetic nodular heterotopia nodular heterotopia MONDO:0016292 Periventricular nodular heterotopia (PNH) is a brain malformation, due to abnormal neuronal migration, in which a subset of neurons fails to migrate into the developing cerebral cortex and remains as nodules that line the ventricular surface. Classical PNH is a rare X-linked dominant disorder far more frequent in females who present normal intelligence to borderline intellectual deficit, epilepsy of variable severity and extra-central nervous system signs, especially cardiovascular defects or coagulopathy. The disorder is generally associated with prenatal lethality in males. SCTID:253151003 https://www.ncbi.nlm.nih.gov/pubmed/15146004